Synvisc-One®

Synvisc-One (hylan G-F 20) is a viscosupplement injection for osteoarthritis of the knee. Made from a natural substance that lubricates and cushions your joint, Synvisc-One can provide knee pain relief and improved mobility over 6 months with just one simple injection.

Learn how to make Synvisc-One part of your osteoarthritis treatment plan 

What’s in a joint?

A healthy joint has cartilage and synovial fluid that protect and cushion the bones.

If you are living with osteoarthritis, the cartilage in your joint has worn down and the synovial fluid is no longer able to cushion your joint. When this happens, your bones rub against each other, causing pain, joint stiffness and swelling.

When you get an injection of Synvisc-One, you replace the damaged synovial fluid in your knee with a natural substance that protectscushions and lubricates the joints.

 Cartilage wears away
 Bone spurs may develop
 Joint fluid breaks down

In knees with osteoarthritis, the joint fluid (called synovial fluid) can break down. When this happens your knees no longer have the cushioning and lubrication that they need.

 Synvisc-One replaces joint fluid

Synvisc-One replaces the worn out synovial fluid to relieve the pain and improve the knee joint’s ability to act as a natural shock absorber.

Mother nature knows best.

Synvisc-One mimics healthy young synovial fluid to protect your knee joint.

Healthy young synovial fluid offers the ideal balance of cushioning and lubrication to protect your joints.

Synvisc-One (hylan G-F 20) mimics these superior qualities and hylan-G-F 20 has been shown to provide significant pain relief from osteoarthritis over a long period of time.

SYNVISC/Synvisc-One (hylan G-F 20)

Low molecular weight viscosupplements

What about your other joints?

In addition to Synvisc-One for the knee, hylan G-F 20 is also available simply as SYNVISC® to treat the pain and discomfort of osteoarthritis in the hip, shoulder and ankle.

Talk to your doctor about SYNVISC® and Synvisc-One to see which is the right choice for you!

SYNVISC® goes to work right where the pain begins without the need for surgery!

  • Lubricates and cushions your joint
  • Decreases pain and discomfort
  • Helps you get back to your daily activities
  • Helps protect your cartilage against further damage
  • Approved for use multiple times
  • Could delay the need for total knee replacement surgery

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Synvisc-One®

Synvisc-One is a treatment to decrease pain and discomfort associated with osteoarthritis that replaces the diseased synovial fluid in your knee with a gel-like substance that is very similar to the synovial fluid found in healthy, young joints.


For Canadian residents only.

Last updated: 12/16/2014
Copyright © 2022 sanofi-aventis Canada Inc. All rights reserved.
Synvisc is a registered trademark of Genzyme Corporation.


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