What is SYNVISC®/Synvisc-One®?

SYNVISC® and Synvisc-One® (hylan G-F 20) are gel-like fluids used as a temporary replacement of and supplement for synovial (joint) fluid. They are used to treat pain associated with OA.

SYNVISC®/Synvisc-One® is a treatment that can:

Decrease pain and discomfort

Allow for more extensive movement of the joint

Protect cartilage cells against certain physical and chemical damage (from in vitro evidence)

How does SYNVISC®/Synvisc-One® work?

SYNVISC® and Synvisc-One® are viscosupplements. They are biologically similar to hyaluronan. Hyaluronan is a component of synovial fluid that is responsible for its viscoelasticity. Synovial (joint) fluid lubricates the joint and acts as a shock absorber.

Normal knee joint showing the bone, joint capsule, synovial membrane, synovial fluid, and cartilage versus an OA knee joint showing a bone spur, thinned cartilage, and bone ends rubbing together. Image from Australian Orthopaedic Association.

How do SYNVISC® and Synvisc-One® compare?

A healthcare professional will help you determine which product is right for you; however, here are some key similarities and differences:

  SYNVISC® Synvisc-One®
Number of injections per treatment 1–3 1
Joints

Knee
Ankle
Shoulder
Hip

Knee
Possible duration of effects* Up to 26 weeks of pain relief. Prospective clinical data in knee OA patients have shown benefit of treatment up to 52 weeks. Prospective clinical data in knee OA patients have shown benefit of treatment up to 26 weeks, following a single Synvisc-One® injection.
Patient speaking with their healthcare professional

Ready to try SYNVISC® or Synvisc-One®?

Stock photo – posed by models.

* Each person responds differently to treatment and will experience different relief.

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