What is SYNVISC®/Synvisc-One®?
SYNVISC® and Synvisc-One® (hylan G-F 20) are gel-like fluids used as a temporary replacement of and supplement for synovial (joint) fluid. They are used to treat pain associated with OA.
SYNVISC®/Synvisc-One® is a treatment that can:
Decrease pain and discomfort
Allow for more extensive movement of the joint
Protect cartilage cells against certain physical and chemical damage (from in vitro evidence)
How does SYNVISC®/Synvisc-One® work?
SYNVISC® and Synvisc-One® are viscosupplements. They are biologically similar to hyaluronan. Hyaluronan is a component of synovial fluid that is responsible for its viscoelasticity. Synovial (joint) fluid lubricates the joint and acts as a shock absorber.

How do SYNVISC® and Synvisc-One® compare?
A healthcare professional will help you determine which product is right for you; however, here are some key similarities and differences:
SYNVISC® | Synvisc-One® | ||||||
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Number of injections per treatment | 1–3 | 1 | |||||
Joints |
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Possible duration of effects* | Up to 26 weeks of pain relief. Prospective clinical data in knee OA patients have shown benefit of treatment up to 52 weeks. | Prospective clinical data in knee OA patients have shown benefit of treatment up to 26 weeks, following a single Synvisc-One® injection. |

Ready to try SYNVISC® or Synvisc-One®?
Stock photo – posed by models.
* Each person responds differently to treatment and will experience different relief.
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